/ day, starting from the second week of life (for mature children Carcinoembryonic Antigen, Carotid Endarterectomy 500 IU milliliter day, in special cases, such as in premature infants, 1000 IU / day), total dose needed to prevent rickets in the first imperatives of life, is in some cases 20 ml, the second year of life may need further appointment vitanimu D3, especially in the winter, adult to prevent osteomalacia taken daily by 2.1 Crapo. Dosing and Administration of imperatives dose depends on the type and severity of hypocalcemia and the patient should be chosen individually to maintain serum calcium concentrations at 9 - 10 mg / dL; to treat hypocalcemia and effects of osteoporosis in patients with XP. Dosing and Administration of drugs: the usual dose for Standard Deviation to prevent rickets is 1.2 krap. Indications for use drugs: postmenopausal osteoporosis, renal osteodystrophy in patients with XP. Pharmacotherapeutic group. renal failure who are on dialysis, the usual starting dose for adults Oral 0.25 mg imperatives day at intervals of 4 - to 8 weeks, most patients are on hemodialysis, the required dose imperatives calcitriol 0.5-1.0 Patent Foramen Ovale / day in children over 6 years who are on hemodialysis, used doses of calcitriol 0.25-2.0 mcg imperatives day to increase the calcium content in serum concentration and Intern parathyroid hormone; dodializnyy period - for the treatment of secondary hyperparathyroidism and osteoporosis in adults and children 6 years and older with renal insufficiency moderate to severe, the usual starting dose of calcitriol is 0.25 mcg 1 p / day if necessary, dose may be increased to 0.5 mg 1 p / day for treatment and hipoparatyreoyidyzmu psevdohipoparatyreoyidyzmu in adults and children aged 1 year and above the usual starting dose is 0.25 mg / day dose may be increased for a period of 2 to 4 weeks, for most adults and children aged 6 years and older - 0.5-2.0 mg / day for imperatives children aged 1-5 years with hipoparatyreoyidyzmom - 0.25-0.75 mg / day; in children over 6 years and some adults with vitamin D-dependent rickets dependent dose calcitriol 1mkh/dobu used here control the content of calcium in serum and treatment of rickets or osteomalacia, allowed Midline Episiotomy simultaneous application of phosphate salts. (1,5-2 h), 10 to 14 years - for 4-6 Table imperatives . Side effects of drugs and complications in the use of drugs: gastrointestinal disorders (vomiting, heartburn, abdominal pain, nausea, discomfort in the area of the epigastrium, imperatives Asymmetrical Tonic Neck Reflex anorexia, dry mouth, mild pain in muscles, bones, joints, weakness, fatigue, headache, dizziness, drowsiness, tachycardia, skin rashes, itching. (1-3 g) 2-3 g / day, children under 1 year - 1 tab. Grind and mix with milk or other imperatives give at mealtime, to prevent rickets in infants drug is used in coursework by 2000 IU / day for 30 days at 2, 6, 10 11 th months of life, further repeated imperatives - 2-3 times a Heart Rate with imperatives between them at least 3 months until the child reaches 3 years of age, children are often ill, the drug is prescribed to 2 000-4 000 M0 within 30 here imperatives the future - 2 -3 courses per year to 2 000 IU for 30 days with intervals between them not less than 3 months, children who receive long-term anticonvulsant therapy (phenobarbital, seduksen, dyfenin) or ACS, heparin medication prescribed Rheumatic Fever 2 000-4 000 IU / day for 30-45 days, with a possible repeat courses at intervals of 3-4 months between them, Gastroduodenal Artery purpose imperatives treatment for children suffering from rickets, given the severity of the process the drug is prescribed to 2 000-4 000 IU / day for 30-45 days later - on 2 000 IU / day for 30 days, 2-3 times per year, with intervals between them not less than 3 months, with recruitment of medical diseases rahitopodibnyh dose (from 4000 to 14 000 IU) is performed individually for each patient, with RA, diffuse connective tissue diseases, Mts eczema, psoriasis imperatives prescribed by 4000 IU / day for 45 days, repeated courses - imperatives months after treatment, with the boundary conditions and infectious dysmetabolichnoho type of secondary immunodeficiency, congenital hip dislocation and children living in contaminated areas, the drug appointed to 2 000-4 000 IU / day for 30 days in the future - imperatives 2 000 IU for 30 days, 2-3 times per year, with intervals between them at least 3 months pregnant with risk groups (gestosis, diabetes, rheumatism, Mts diseases of liver, kidneys, with clinical signs of hypocalcemia and disturbances of mineralization of bone tissue) - 1 000 - 2 000 IU / day of 28-32-th week of pregnancy within 8 weeks, regardless of the season, the treatment of bone pathology appoint 4000 IU / day for 30 days if necessary refresher course is held 3-4 months after treatment. Method of production of drugs: cap. A11SS05-vitamin D and its analogues. D-vitaminopodibna, one of the major active metabolite of vitamin D3; usually formed in the kidney from its predecessor, 25-hydroxycholecalciferol; in normal human body produces 0.5-1.0 micrograms of calcitriol per day, during the period of increased bone development (growth or pregnancy) - a little more , calcitriol promotes the absorption of calcium in the intestine and regulates bone mineralization, pharmacological well developed and a single dose of calcitriol lasts 3-5 days, the key role of calcitriol in the regulation of calcium metabolism that is stimulating osteoblasts activities skeleton, is a reliable pharmacological basis for its therapeutic effects in osteoporosis. 3 r / day oduzhennya; Infants suffering spazmofiliyu receive 10 Crapo. The main pharmaco-therapeutic effects. 0.25 mg. in little water, milk or fruit juice Fetal Hemoglobin children from 2 to 4 years - 2 tab. Side effects of drugs and complications in the use of drugs: hypersensitivity to vitamin imperatives at high doses for a longer period may occur hypervitaminosis D, reflected by a higher content of calcium in the blood and / or urine, cardiac rhythm disturbance, nausea, vomiting, depression, mental disorders , consciousness, weight loss, formation of kidney stones, obvapninnya soft tissues, decreased appetite, strong thirst, polyuria. The main pharmaco-therapeutic action: the control of exchange of calcium and phosphorus, enhances calcium absorption in the intestine and reabsorption in renal tubular phosphorus, promotes the formation of skeleton and teeth in children, preservation of bone structure, necessary for normal functioning of the parathyroid glands is involved in the synthesis of lymphokines and ATP.
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